Development and Optimization of Ondansetron Transdermal Drug Delivery System

Abdalnaser Taha Dongos Osman , Usha G.K, S.Rajarajan and Tejas.R

Ondansetron delivery through oral route suffers low bioavailability due to first-pass metabolism. Several disadvantages with oral, intravenous and rectal administration include extensive liver metabolism, low bioavailability, vomiting before drug absorption, rapid onset that may result in undesirable side effects, and high clearance. Therefore, the objective of the present study was to optimize ondansetron transdermal patch formulation. Ondansetron transdermal patches is prepared by solvent casting method. The DOE was to optimize the critical process parameters to achieve desired Folding endurance, Thickness, drug release at 12 hours. Box Behnken quadratic design was selected to carry out with 13 experimental runs for the formulation of transdermal patch. The analysis was performed actual v/s predicted and optimization were conducted in quadratic model.

Keywords:Ondansetron, Transdermal Drug Delivery System, Box Behnken Design